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Studies indicate that long-term use of KD conditions vitamin C, biotin, and zinc deficiencies ( Vitamin C is an important antioxidant that plays a key role in collagen synthesis (241, 242)

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In a small human component of the same study (n=20), people receiving intra-articular hyaluronic acid injections combined with semaglutide showed thicker cartilage, measurable cartilage growth, and lower pain scores after 24 weeks