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Because the elimination half-life is approximately one week and steady-state exposure builds over 4 to 5 weeks of once-weekly administration, exposure declines slowly, which is why the labels specifically contemplate a prolonged period of observation and treatment rather than a short one
But once youre pregnant, the official guidance is to stop taking the medication
The discomfort is typically minimal and brief
10.1161/01.hyp.7.6_pt_2.ii161 149 HealyJ
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