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UUO kidneys presented severe morphological lesions characterized by tubular dilation, tubulointerstitial expansion, and interstitial collagen deposition
In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]
Oral: 100500 mcg, 12 times daily
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