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Selective pretreatment of endothelial cells with methylene blue before co-culture with untreated rabbit pulmonary arterial smooth muscle produced a reduction in rabbit pulmonary arterial smooth muscle cyclic guanosine monophosphate levels of a magnitude comparable with that seen in cocultures of methylene blue pretreated rabbit pulmonary arterial smooth muscle with untreated endothelial cells, and which was partially prevented by superoxide dismutase
However, absorption of oral glutathione may be limited because the digestive system breaks it down before it reaches the bloodstream
Our study provided valuable evidence for early clinical interventions and the identification of the risk of gastrointestinal toxicities
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