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PLoS ONE 8 , e76542 (2013)
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Meta-analyses suggest that GLP-1RAs can lead to an average BMI reduction of 12 kg/m 2 , a decrease in waist circumference of several centimeters, and total weight loss of 5%7% in some studies ( In clinical practice, weight losses of 5% and 10% are commonly used thresholds for clinical significance. PCOS guidelines state that a weight reduction of 5% can significantly improve insulin sensitivity and hyperandrogenic load, while 10% weight loss is strongly linked to restored ovulation and improved pregnancy rates ( At the level of body composition, limited DEXA and CT evidence suggests that GLP-1RAs primarily reduce fat massspecifically visceral fatwhile relatively preserving lean mass ( It must be emphasized that this foundational effect is not merely about a change in the numbers on a scale
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