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Cell 167:843857.e814 Ethics declarations Funding This work was supported in part by Deutsches Zentrum fr Diabetesforschung (DZD), Alexander von Humboldt Foundation, Helmholtz Alliance ICEMED through the Initiative and Networking Fund of the Helmholtz Association, and the Helmholtz cross-program topic Metabolic Dysfunction

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For competitive athletes, IGF-1 and its analogs, including LR3, are banned at all times, in and out of competition, under Section S2 of WADA's Prohibited List (Peptide Hormones, Growth Factors, Related Substances and Mimetics)