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There are over 20 identified gut peptides within the GI tract, many of which play a key role in energy and glucose homeostasis, with the following sections focusing on the incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), CCK, and several others

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Due to distinct tissue expression of receptors, MT-2 is incorporated alongside selective antagonists, genetic models, or specific interventions to attribute observed effects to receptor subtypes

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Retatrutide, a triple GLP-1/GIP/glucagon receptor agonist, is studied in metabolic research

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26%) [Figure 11.2]

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