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Subcutaneous injection bypasses all of these barriers except plasma half-life, which for unmodified small peptides is generally very short (minutes to low hours, based on class-level pharmacokinetic data for similar unmodified peptides)

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IV administration also introduces risks that oral supplementation does not: Contamination or excessive endotoxin exposure Sterility and compounding failures Infusion reactions Venous irritation or infection Dosing errors Additional cost and clinical complexity The FDA has reported adverse events among patients who received injectable compounded glutathione made with an unsuitable dietary ingredient

doi: 10.1016/j.clim.2020.108544 29 JainS