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However, the application of CeO x -based nanozyme to suppress ROS levels still faces the major challenge that Ce (III) would rapidly react with ROS to oxidize Ce (IV) in the pathological microenvironment, disrupting the original redox cycle to restrict its catalytic activity, so that it is essential to introduce an extra stabilizer to maintain the nanozyme function 18

Caspase 3 plays a central role in apoptosis, either initiated through the extrinsic or intrinsic pathways and is considered a marker of cardiomyocyte apoptosis after open-heart surgery [11]

not cleared or approved by the FDA