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In medicine, a slightly less potent treatment that a person is willing and able to take consistently can sometimes be more useful in the real world than a theoretically stronger treatment they never start or quickly stop

The area under the curve (AUC) is shaded

Genentech Headquarters: South San Francisco, California, USA Number of employees: 13,500 Year founded: 1976 Revenue (2025): $14.2 billion Forbes overall rank: 127 As a wholly-owned member of Roche Holding AG, Genentech contributed to the groups robust 2025 performance

dose adjustments of concomitant medications may be necessary Renal function : Dehydration from gastrointestinal side effects may precipitate acute kidney injury, particularly in patients with pre-existing renal impairment