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3) starting with an image in which multiple endosomal puncta were visible, images were thresholded using the auto-selected threshold from the Triangle algorithm, and the same threshold was used for all images

AD is characterized by a decade-long prodromal stage, and dementia diagnosis typically occurs in the late biological stage of AD, by which time substantial amounts of A and tau proteins have accumulated in the cortex [101]

Severe hypoglycemia was rare across all studies, but mild hypoglycemia was not uncommon and mostly associated with the use of sulfonylureas [17,19,76]