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Biologic-nave obese patients appear to derive the greatest benefit, while those already on IL-17 or IL-23 inhibitors show more modest additive effects, consistent with a predominantly weight-lossmediated mechanism
Crucialmente, este efecto es glucosa-dependiente , lo que significa que la estimulacin de insulina ocurre principalmente cuando los niveles de glucosa estn elevados, reduciendo significativamente el riesgo de hipoglucemia en monoterapia (aunque este riesgo aumenta cuando se combina con insulina o sulfonilureas)
The lysate was clarified using centrifugation and split into two fractions
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