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Female physiology matters: women metabolize compounds differently and often start peptides during perimenopause, when hormone shifts change how the body responds

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Researchers have documented the safety profile observed in published Phase 2 research as predominantly gastrointestinal effects (nausea, diarrhoea, vomiting) typical of the incretin class, occurring most prominently during dose escalation and tending to decline with continued exposure (PMID 39515565, PMID 41785010)

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