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Further, inhibition of TRPM7 activity attenuates RA articular cartilage destruction and chondrocyte ferroptosis by suppressing the PKC-NOX4 axis (129)
Kumar AN, Naidu JN, Satyanarayana U, Anitha M, Ramalingam K
Activated T cells and macrophages in the synovium form an environment conducive to ferroptosis and inflammation, and also induce ROS production in a positive feedback manner, thus promoting the release of pro-inflammatory factors into the synovium and synovial fluid and further amplifying synovial inflammation (84)
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