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[See Dosage and Administration.] Hypersensitivity Reactions There have been postmarketing reports of serious hypersensitivity reactions in patients treated with Januvia

First, the escalation timeline may be extended if GI tolerance is a concern

Conclusion Counseling patients on GLP-1 therapies is evolving alongside the treatments themselves

The SUSTAIN and SURPASS trial serieswhich evaluated these medications for diabetes and weight lossdocumented cycle changes as a potential side effect, though severe cases were uncommon