approved glp-1 agonists Receptor and Other Drugs GLP-1 RAs gain popularity as

Recent analyses have raised questions about psychiatric side effects, particularly mood changes and anxiety. Patients with asthma may be at increased risk of respiratory complications, and nutrient deficiencies can occur with long-term therapy. Monitoring mental health and nutritional status should be part of any GLP-1 program

Pfister D, Schonberger H, Rank CM, et al

It is delivered subcutaneously once daily and measured in micrograms

Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)