Further microscopic research revealed that melanosome transport between cells requires a number of steps, including bidirectional long-range transfer to the apical surface on microtubules, transfer to actin filaments, irreversible short-range transfer by actin dynamics followed by binding to the cell membrane (130)
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J Pharmacol Exp Ther 282(3):15331540 Thompson RA, Isin EM, Li Y, Weidolf L, Page K, Wilson I, Swallow S, Middleton B, Stahl S, Foster AJ, Dolgos H, Weaver R, Kenna JG (2012) In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs
But heres a truth we've seen play out time and time again: all of that effort, precision, and quality can be completely undone by one simple mistake