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A Kinetex UPLC C18 column (100 mm*2.1 mm, 100 A, phenomenex, UK) was used for the reversed phase separation

Product Specifications Components and CAS Numbers : Cagrilintide: CAS 1415456993 Semaglutide: CAS 910463682 Molecular Weights : Cagrilintide: 4409 g/mol Semaglutide: 4113.6 g/mol (approx.) Chemical Formulas : Cagrilintide: CHNOS Semaglutide: CHNO Purity : Typically supplied as highpurity peptides (often 98% by HPLC) with identity confirmed by mass spectrometry

2-HG has also been shown to inhibit CD12 expression on DC and inhibit CXCL-10 secretion, thus preventing T-cell recruitment

These hormones can stimulate or inhibit the growth of gut epithelial cells, control gut motility, and modulate the immune response