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The analysis of this compound relies on chromatographic separation techniques that exploit differences in physicochemical properties between target molecules and matrix components

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As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]

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