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it is a regulatory one that limits peak tissue receptor activation
However, in contrast to the tumour-suppressive effects described above, there is evidence that CDO1 can have a tumorigenic effect associated with aggressive glioblastoma, since its overexpression was detected in these tumours
Up-regulation: towards cysteine and glutathione peroxidase system (transulfuration)
Lipid peroxidation is further amplified by lipid oxygenases (LOXs) and ROS generated through the Fenton reaction, driving the process of ferroptosis ( Apart from GPX4, several key intracellular factors inhibit ferroptosis
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