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This escalation pattern is consistent with other GLP-1 receptor agonists and should be considered when designing preclinical study protocols that aim to replicate clinical pharmacokinetics

The most common include tremor, impaired balance, rigid muscles, slowed movement, changes to speech, disordered sleep and changes to memory and cognition

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Microtubules are mostly nucleated by the -TuRC, which contains -tubulin and several associated proteins referred to as -tubulin complex proteins (GCPs)