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Reaction products from a standard MSA-DH assay were fractionated by preparative HPLC separation (compare Figure 4A) and the malate containing fraction was subjected to enantiomeric separation on a Chirex ligand exchange phase 3126
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The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)
Studies on the beneficial effects of L-carnitine on the cardiovascular system began as early as 1937
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