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Your gut cells release GLP-1 after every meal, every day, as part of the ordinary process of coordinating digestion, blood sugar, and satiety
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Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks
Rybelsus is also expensive without coverage and is usually only approved for diabetes
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