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[28] Other side effects reported were dyspepsia, constipation, abdominal pain, dizziness, and hypoglycemia
In the SURPASS-2 trial, which compared tirzepatide to semaglutide 1 mg (a GLP-1 receptor agonist) over 40 weeks, participants receiving tirzepatide achieved A1C reductions of 2.01%, 2.24%, and 2.30% from baseline with the 5 mg, 10 mg, and 15 mg weekly doses, respectively
GLP-1 therapy requires sustained monitoring for pancreatitis risk, dehydration, rapid weight loss complications, and medication interactions
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