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In March, Roche and Zealand released Phase 2 clinical trial data for a once-weekly injection of petrelintide showing nearly 10% weight reduction among participants with minimal side effects

GLP-1R agonist analogues with turn-promoting -amino acids are more active than those with helix-promoting -amino acids at the fourth position Non-traditional substitutions can yield GLP-1 analogues that show distinctive behavior and these might also provide insight into agonist conformation

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6 Additionally, insulin resistance may lead to dopamine degeneration and disrupted glucose metabolism in several brain regions, further exacerbating the progression of PD