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Pathophysiology of CHE Central role of ammonia in CHE CHE pathophysiology is centered on impaired liver functional reserve and neurocognitive dysfunction arising from brain alterations, but also involves complex multi-organ interactions, in which hyperammonemia, inflammation, sarcopenia, and the gutliver axis play critical roles ( Fig
Long-term cost-effectiveness of two GLP-1 receptor agonists for the treatment of type 2 diabetes mellitus in the Italian setting: Liraglutide versus lixisenatide
However, the potential gastrointestinal side effects, including the risk of acid reflux due to delayed gastric emptying, present a challenge in its clinical use
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