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The CMAJ guidance A guidance article published in the Canadian Medical Association Journal (CMAJ) on glucagon-like peptide-1 receptor agonists during pregnancy and lactation concluded that while the safety data is limited, the pharmacological properties of GLP-1 agonists (large molecular weight, poor oral bioavailability) suggest low theoretical risk during breastfeeding
Levison, R.A
Considering these findings observed across a large, real-world cohort, the researchers concluded that avoidance of semaglutide based solely on concerns regarding the risk of NAION may not be warranted, as its potential benefits for blood glucose control and cardiovascular health likely outweigh its potential risks.
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