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Hypokalaemia (low potassium) is clinically significant as it can cause dangerous cardiac arrhythmias, especially in patients taking diuretics, ACE inhibitors, or other medications affecting electrolyte balance

The proportion of participants achieving clinically meaningful weight reduction was also significantly higher with semaglutide: 79 percent achieved at least 5 percent weight loss 63 percent achieved at least 10 percent 50 percent achieved at least 15 percent 30 percent achieved at least 20 percent These outcomes were accompanied by significant improvements in physical function, as measured by a validated quality-of-life tool

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Other randomized control trials show similar results, too, with the best results coming from supervised exercise exceeding the 150-minute/week guideline (Lundgren, 2021