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The practice of microdosing GLP-1 receptor agonists is largely experimental and off-label
Encountering a weight loss plateau on tirzepatide warrants systematic evaluation and evidence-based management strategies rather than immediate treatment discontinuation or dramatic intervention
One specific class of the oral glucose-lowering drugs, SGLT-2i, is particularly interesting given their effects on glycemia, weight, and cardiovascular protection
Opioids and anticholinergics can further slow GI motility, potentially leading to severe constipation or symptoms of gastroparesis
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