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Intermenstrual bleeding (bleeding between periods) or postcoital bleeding (bleeding after sexual intercourse) should always be evaluated, as these symptoms require exclusion of cervical or endometrial pathology

Primary endpoints included cataracts, oculomotor binocular dysfunction, visual impairment and blindness, visual disturbances, dry eye disease, and ametropic accommodative dysfunction, all identified through ICD-10-CM coding (Supplementary Data 3)

The landmark SURMOUNT-5 trial , published in the New England Journal of Medicine, was the first head-to-head trial comparing the two medications in adults with obesity but without type 2 diabetes