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Anaplerotic entry into the tricarboxylic acid cycle supports biosynthesis but can also signal mitochondrial congestion if oxidative capacity is limited
The newly recruited monocytes express a pro-inflammatory phenotype (Ly6C hi ) [103] and there is evidence that during the very early phase of their recruitment (812 h after APAP) these cells can cause a temporary mild aggravation of the injury [108]
Too much glutathione from non-natural peaks may affect cell processes in ways we dont fully understand yet
J Inherited Metab Dis 15 : 419422
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