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Besides being a potential source of more reactive free radicals via Fenton reaction, physiological generation of H 2 O 2 fulfills a second messenger role and can be transported across membranes by aquaporins, a family of proteins that act as peroxiporins (Sies, 2014)
It may also have anti-aging effects and may help to reduce the risk of certain diseases, such as diabetes and cancer
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MC1R activation on melanocytes triggers a signaling cascade through cyclic AMP (cAMP) and the MITF transcription factor, upregulating tyrosinase and other melanogenic enzymes
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