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In the STEP-3 trial (N=611), which combined semaglutide 2.4 mg with intensive behavioral therapy, GI side effects were most frequent during weeks 1 through 8 of each dose tier and declined by week 12 at the same dose [16]
Many individuals find that consuming smaller, more frequent meals rather than large portions helps minimise digestive discomfort
Researchers note that while traditional renin-angiotensin-aldosterone system inhibition remains foundational in HF with reduced ejection fraction (HFrEF), newer therapies may enable more personalized treatment pathways based on comorbidity profiles and disease phenotype
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