386,387 Autophagy-inducing small molecules and natural compounds Additional autophagy-inducing agents include lithium, which induces autophagy via inhibition of inositol monophosphatase and reduces tau and amyloid- aggregation in AD models, 388 and SMER28, a small-molecule enhancer of rapamycin that promotes autophagy and reduces tau and -synuclein aggregation in AD and PD models
Katsumata, U., Miura, M., Ichinose, M., Kimura K., Takahashi, T., Inoue, H., Takishima, T., Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats, Am
In cell-based and biochemical laboratory research, GHK-Cu has been investigated for its copper-binding behaviour and, in preclinical models, for associations with pathways relating to gene expression, extracellular matrix turnover and oxidative-stress responses
10 As noted in a November 2017 paper in Free Radical Biology and Medicine: 11 "Epigenetics is a rapidly growing field that studies gene expression modifications not involving changes in the DNA sequence