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If monotherapy proves insufficient, clinicians may consider: Optimising the current medication (ensuring proper technique for Saxenda injections, addressing side effects, reinforcing dietary adherence) Switching to an alternative medication rather than adding a second Intensifying lifestyle support through referral to specialist weight management services Evaluating for bariatric surgery in patients meeting criteria (typically BMI 40 kg/m or 35 kg/m with comorbidities, with consideration for people with recent-onset type 2 diabetes at BMI 30-34.9) Combination pharmacotherapy is not standard practice and would typically only be considered by specialists in weight management services after careful evaluation

World J Gastrointest Surg

J Pharm Sci 1995;84(5):627-633

The above study from Diabetes Obesity Metabolism said: The average change in body weight was similar in the two groups (-3.7 kg with injectable and -3.3 kg with oral at 18 months), but more new users of injectable semaglutide lost 5% body weight. According to Dr