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Most of these metabolites correspond to Phe and Phe-derived compounds, reflecting the metabolic overflow caused by Phe accumulation in PKU similar than in blood (Rausell et al., 2019

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

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It works by mimicking hormones involved in appetite control and blood sugar regulation, making it easier to reduce calorie intake without feeling constantly hungry