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doi: 10.3390/nu14112217 53
It is well established that overweight and obesity increase a persons risk of cardiovascular events, but the concept of treating obesity to reduce cardiovascular complications has been hampered by lack of evidence that lifestyle or pharmacologic interventions for overweight or obesity improve cardiovascular outcomes, says Dr
Franklin ZJ, OHarte FPM, Irwin N (2014) Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice
A different randomized, double-blind, placebo-controlled clinical trial demonstrated that daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study induced a significant subjective improvement of penile erectile function, as assessed through standardized OLeary questionnaire for ED, although without a significant improvement of penile vascular parameters assessed by basal PDU, in 29 middle-aged/elderly men affected by organic ED of mixed etiology and unknown severity, therefore reporting, in line with the results of the current study, a discrepancy between subjective and objective improvement in erectile function [28]
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