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Previous studies have estimated that the economic burden of sarcopenia in the United States accounts for approximately 1.5% of total national health expenditures [7], with annual per capita healthcare costs rising by $2,315.7 in individuals with sarcopenia [8]
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however these variants explained only a small percentage of the genetic variation of the disorders, further supporting the concept that epigenetic processes play an important role [17]
EPP is a rare photodermatosis caused by ferrochelatase deficiency , producing phototoxic protoporphyrin IX accumulation in erythrocytes and skin that causes severe pain and burning on exposure to visible light
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