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Reduces diabetes risk: The HERS trial found that estrogen-based HRT was associated with a 35% reduced incidence of type 2 diabetes [12]
Due to its mechanism of action regulating appetite and insulin secretion, it may impact multiple systems within the body
This reduces strain on healthcare systems and expands global access
Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol
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