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Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets

However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)

Off-Label Prescribing Considerations Some healthcare providers are already discussing GLP-1 therapy with patients at high risk for both metabolic disease and dementia