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As reported previously in C57BL/6N vs C57BL/6J islets, the glucose regulation of mitochondrial (but not cytosolic) E GSH and of NAD(P)H autofluorescence was markedly improved in N5-WT vs N5-Tr islets, confirming the role of NNT in mitochondrial redox regulation

Owing to the pleiotropic effects of GSH on cell functions, it has been quite difficult to define the role of GSH in the onset and/or the expression of human diseases, although significant progress is being made

Ethics declarations Ethics approval and consent to participate The animal protocol employed in this study was approved by the Animal Experimentation Committee of Jinan University (IACUC-20191212-02)

[7] High-dose methionine may antagonize the therapeutic effect of L-dopa-carbidopa regimens by increasing peripheral methylation of the drug complex, potentially reducing central bioavailability