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FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis
Compression fractures
Keywords Information Type Research Article Information Copyright The Author(s), 2026
Cuando las administran profesionales cualificados, las inyecciones de glutatin son generalmente seguras, pero siempre deben discutirse los posibles efectos secundarios y la idoneidad individual
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