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The nuclear respiratory factors (Nrf1 and Nrf2) that initiate the transcription of genes linked to mitochondrial biogenesis are co-activated by SIRT1 through the activation and deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) (Scarpulla, 2011), a master regulator of mitochondrial biogenesis

doi: 10.3390/nu11092101 109 GuloyanV.OganesianB.BaghdasaryanN.YehC.SinghM.GuilfordF.et al

Examples include: Collagen peptides : Commonly found in bovine or marine sources, often used in supplements and topical formulations for boosting skin elasticity

Regulatory status and legality 2