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10.1210/en.2016-1839 28

Always talk with your doctor before starting any new supplement, especially if you have an underlying condition

Evidence has indicated that regulating the gene expression of TRP-1 and TRP-2 by cAMP is directly associated with MITF, which binds to the M-box sequence (AGTCATGTGCT) located in the tyrosinase distal elements (TDEs) after its activation (22)