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During oxidative stress, Nrf2 translocates into the nucleus to regulate the transcription and expression of antioxidant response elements (ARE), activating the intracellular antioxidant enzyme system to eliminate excess ROS and bolster the cells antioxidant capacity (Lu et al., 2016)

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Initial studies in animal models suggested that pineal peptide extracts containing the AEDG sequence might extend lifespan and improve various markers of aging

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