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Intravenous or intramuscular delivery bypasses the intestinal lumen, preventing any interaction with microbial enzymes responsible for TMA formation
In another Clinical Trial, Thomas et al
Several trials, such as the United Kingdom Prospective Diabetes Study (UKPDS) and Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE), have demonstrated that appropriate control of blood glucose is beneficial for the reduction of long-term cardiovascular complications [4, 5]
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