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( E and F ) Body weight gain in WT ( E ) and Bbs5 / ( F ) mice at 24 and 36 hours after leptin injections
However, as NAC regiment was intensified in severe IPTB (using intravenous NAC boluses), it remains to be determined whether the observed differences are due to the severity of IPTB itself or to treatment intensity
Recent research has shown that silymarin reduces acute toxic liver injury caused by APAP by increasing hepatocyte proliferation, decreasing CYP2E1 activity and expression, and decreasing the production of toxic metabolites (Yang et al., 2022b)
Symptoms are usually mild and may include redness, itching, bruising, tenderness, a small lump, or a rash at the injection site
