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doi: 10.1038/s41416-023-02204-2 55 MorettiIFLerarioAMSolaPRMacedo-da-SilvaJBaptista M daSPalmisanoGet al
Elevated intracellular cAMP activates protein kinase A (PKA), which phosphorylates the cAMP response element-binding protein (CREB), driving transcription of melanogenesis-related genes including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT) in melanocyte models
They replicate healthy tissues and can be produced from natural or synthetic polymers
If someone has a diagnosed deficiency, especially due to absorption issues, their provider might start them on weekly injections
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