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It is a dual GIP/GLP-1 receptor agonist, the first and currently only FDA-approved medication in its class
However, mice with depletion of hepatic glutathione showed significantly elevated whole-body energy expenditure (Figure 2B) and oxygen consumption (Figure 2C), indicating increased metabolic rate
While still manageable, this represents a more than 20-fold increase compared to Mazdutides discontinuation rate
That is why a full 1mL (100-unit) insulin syringe becomes necessary once you reach Phase 3 of the titration
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