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Glutathione peroxidases Five selenium-containing glutathione peroxidases (GPx1-4 and GPx6) have been identified: GPx1 (cytosolic GPx), GPx2 (epithelial cell-specific GPx first identified in intestinal lining and lungs), GPx3 (highly expressed in thyroid gland and kidneys), GPx4 (phospholipid-hydroperoxide GPx

Experimental investigations have shown that certain microbial metabolites, particularly SCFAs like butyrate and propionate, operate as HDAC inhibitors, increasing chromatin accessibility at BDNF promoter areas (particularly promoters I and IV)

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